1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Università di Ferrara, Ferrara, Italy, 3Uiversity of Bari, Bari, Italy, 4University of Catania, Catania, Italy, 5Arcispedale "S.Anna", Ferrara, Italy, 6Policlinic Foundation San Matteo IRCCS, Pavia, Italy, 7Arcispedale “S. Anna”, Ferrara, Italy