Abstract #0110

In vivo detection of hypothalamic glucose metabolism in HFD and regular fed mice

Blanca Lizarbe¹, Antonie Cherix¹, Lijing Xin², Hongxia Lei^2,3, and Rolf Gruetter^1,3,4

¹Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Animal imaging and technology core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Lausanne, Switzerland, ³Department of Radiology, University of Geneva, Geneva, Switzerland, ⁴Department of Radiology, University of Lausanne, Lausanne, Switzerland

Obesity is a pandemic syndrome that leads to reduced life expectancy, increasing the risk of heart disease, type-2 diabetes and some type of cancers. Noteworthy, to understand the mechanisms of obesity onset and development, several animal models, such as administration high fat diets, have been developed. We used ¹H-[¹³C] MRS methods in regular and in high fat diet fed mice to investigate the effects of high caloric diets and obesity in the hypothalamus, its effects in glucose metabolism and metabolic fluxes in neurons and glia. We found differences that suggest impaired glucose metabolism in the hypothalamus of obese mice.

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