Identifying carotid plaque inflammation using high and low molecular weight contrast agents
Jason Kraig Mendes1, Scott McNally1, Seong-Eun Kim1, Bradley D. Bolster2, Gerald S. Treiman3, and Dennis L. Parker1
1Radiology, University of Utah, SLC, UT, United States, 2Siemens Healthcare, SLC, UT, United States, 3Department of Veterans Affairs, SLC, UT, United States
Carotid plaque inflammation can be measured with dynamic contrast enhanced (DCE) MRI and is a marker for plaque instability. Despite this, DCE has not become a clinically viable tool in diagnosing carotid plaque instability and the corresponding stroke risk. The barrier to progress is a DCE protocol meeting requirements for clinical use to monitor medical treatment effect or failure. This project overcomes this barrier by developing a reliable and inclusive dual contrast DCE protocol to identify carotid plaque inflammation.
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