Radiation-induced inflammatory response in tumor-bearing immune-compromised mice by SPIO-enhanced T2-MRI
Natalie Julie Serkova1, Kendra M Huber1, Barbara Frederick2, Elizabeth R Kessler3, Thomas W Flaig3, and Brian D Kabanagh2
1Anesthesiology, University of Colorado Denver, Aurora, CO, United States, 2Radiation Oncology, University of Colorado Denver, Aurora, CO, United States, 3Medical Oncology, University of Colorado Denver, Aurora, CO, United States
Clinically, the radiation treatment (RT) is know to trigger an inflammatory response which can be beneficial for overall anti-cancer treatment efficacy. However, in pre-clinical mouse models, the tumor response to the RT is rather heterogenous. Our hypothesis is that tumor-associated macrophages which drive the pro-inflammatory response to the RT, are expressed differently in various mouse strains based on their genetic make-up. The goal of this study was to non-invasively assess the tumor inflammatory response to the RT based on iron oxide-induced changes in T2-MRI after injection of SPIO nanoparticles in two different mouse models with severely (NOD SCID) and moderately (nu/nu athymic) compromised immune system.
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