Incorporation of Finite Pulse Correction for Improved MT-Corrected Multicomponent T2 analysis of Cartilage
Fang Liu1, Alexey Samsonov1, Wally Block2, and Richard Kijowski1
1Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States
Nuclear
magnetic resonance studies have identified multiple water components within
cartilage tissue. Previous studies using steady-state sequences based rapid method
such as mcDESPOT and mcRISE have shown feasibility of multicomponent T2
analysis of cartilage. However, steady-state signal can be influenced by the
finite pulse effect which might lead to biased parameter estimation. In this
study, we incorporated the finite pulse correction in the mcRISE model and demonstrated
the potential MT and finite pulse effect in-sensitive T2 parameters for multicomponent
cartilage relaxometry analysis.
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