Abstract #0058

Assessment of cerebral response to exercise: effects of ageing and cardiorespiratory fitness

Andrew Hale¹, Penny Gowland¹, Paul Greenhaff², and Susan Francis¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Faculty of Medicine & Health Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Although there is a general relationship between age and brain function, habitual physical activity levels may also impact on brain health. We performed a MR study involving low and moderate intensity supine exercise in healthy young and older subjects. We assess the effect of exercise on CBF response in large arteries, regional perfusion and BOLD, and the relationship of grey matter volume with physical fitness and ageing. On exercise there was a clear CBF, perfusion and BOLD response to exercise in young volunteers, whilst a reduced CBF, perfusion and BOLD response to exercise was found in the older volunteers.

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