Daniel J Cox1,2, Hamied A Haroon2, Daniela Montaldi1, and Laura M Parkes2
1School of Psychological Sciences, University of Manchester, Manchester, United Kingdom, 2Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom
Alterations to hippocampal
microstructure may precede gross volumetric changes in ageing, and
these changes may occur preferentially in different hippocampal
subfields. We investigated both established (FA and mADC) and novel
(DOC) measurements of diffusion in these regions, in addition to
volume, in order to determine where age-related changes occurred. The
results showed changes across the majority of subfields for mADC and
FA, but only in left CA 2/3 for DOC measures 1, 3 and >3. We
suggest this could be related to differential degradation of
particular cellular structures in these regions.
