Abstract #0030

Toward Iron Distribution Mapping using Quantitative Susceptibility Mapping (QSM): A Comparison of Histological Iron Concentration Maps with Magnetic Susceptibility Maps

Andreas Deistung¹, Verena Endmayr², Simon Hametner², Hans Lassmann², Jürgen Rainer Reichenbach¹, Simon Daniel Robinson³, Thomas Haider⁴, Hannes Traxler⁵, Evelin Haimburger⁶, Siegfried Trattnig³, and Günther Grabner^3,6

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Jena, Germany, ²Center for Brain Research, Medical University of Vienna, Vienna, Austria, ³High Field Magnetic Resonance Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴University Clinic for Trauma Surgery, Medical University of Vienna, Vienna, Austria, ⁵Center of Anatomy and Cellbiology, Medical University of Vienna, Vienna, Austria, ⁶Department of Health Sciences and Social Work, Carinthia University of Applied Sciences, Klagenfurt, Austria

Quantitative susceptibility mapping (QSM) provides a unique view into cerebral iron distribution in vivo. However, not only paramagnetic iron complexes but also diamagnetic myelin around axons contribute to the magnetic susceptibility. To further validate QSM for iron mapping we present a histochemical-driven approach to quantify iron in post mortem brain tissue and compare the spatial distribution of iron with in situ magnetic susceptibility maps. Direct comparison between histological iron concentration and susceptibility maps revealed excellent correspondence between iron accumulations and elevated susceptibility in deep gray matter and can improve the understanding of biophysical origins of susceptibility variations within brain tissue.

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