Abstract #0028

Imaging Whole Mouse Brain Cytoarchitecture by Quantitative Susceptibility Mapping at 10-μm Resolution

Hongjiang Wei¹, Luke Xie², Russell Dibb³, Wei Li⁴, Kyle Decker³, G. Allan Johnson^3,5, and Chunlei Liu^1,5

¹Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, ²Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, United States, ³Center for In Vivo Microscopy, Duke University, Durham, NC, United States, ⁴Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States, ⁵Department of Radiology, School of Medicine, Duke University, Durham, NC, United States

In this study, we demonstrate that whole brain cytoarchitecture can be revealed by QSM at 10-μm resolution at 9.4T. Using QSM, we are able to reveal exquisite anatomical details such as retina layers of the eyeball, glomeruli in olfactory bulb, barrel cortex, medium-sized spiny neurons in striatum, cell layers of cerebellum, and hippocampus. This ultra-high resolution QSM of the intact mouse brain is a powerful dataset to allow analysis and visualization of the brain cytoarchitecture in 3D.

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