Michal Považan1,2, Gilbert Hangel1, Bernhard Strasser1, Eva Heckova1, Lukas Hingerl1, Stephan Gruber1, Siegfried Trattnig1,2, and Wolfgang Bogner1
1High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria
Ultra-short
echo/acquisition delay MRS spectra have a strong characteristic background
consisting of macromolecule (MM) resonances superimposed on the signal of
metabolites. Typically a single metabolite-nulled MM spectrum is included into
quantification routine to account for this. To detect more prominent regional and pathologic changes,
we replaced this single MM spectrum by individual MM peaks. We found that the MM
peaks in a 2.3-0.5 ppm region are higher in gray matter compared to white
matter, whereas the MM peaks from 2.9 to 3.2 ppm were significantly higher in
white matter of healthy volunteers and one MS patient.
