Ben Jordan1, Tom Roberts1, Angela D'Esposito1, John Connell1, Andrada Ianus2, Eleftheria Panagiotaki2, Daniel Alexander2, Mark Lythgoe1, and Simon Walker-Samuel1
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Centre for Medical Image Computing, University College London, London, United Kingdom
It has previously been shown that compartmental models
of tissue diffusion such as VERDICT can enable access to useful measures of
in-vivo tumour microstructure such as cell radius. However, comparing the
in-vivo values with those measured from histology showed that a discrepancy
exists between the two; histological values were consistently smaller. In this
study, we assess the ability of VERDICT MRI to detect this change in cell
radius by acquiring data (9.4T MRI) both in-vivo and post-fixation. A
significant decrease in cell radius was detected post-fixation, which was supported
by a decrease in the intra-cellular volume fraction.
