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Abstract #4915

Slab registration as a first step towards hippocampus subparts high resolution imaging at 7T

Linda Marrakchi-Kacem 1,2 , Alexandre Vignaud 3 , Johanne Germain 1,2 , Julien Sein 4 , Thomas R. Henry 5 , Cyril Poupon 3 , Lucie Hertz-Pannier 3 , Stphane Lehricy 1,6 , Olivier Colliot 1,2 , Pierre-Franois Van de Moortele 4 , and Marie Chupin 1,2

1 UPMC-Paris6, CRICM, CNRS, UMR 7225, Inserm, UMR-S975, ICM, Paris, France, 2 Aramis project-team, Inria Paris-Rocquencourt, Paris, France, 3 NeuroSpin, CEA, Gif-Sur-Yvette, France, 4 CMRR, University of Minnesota, Minneapolis, MN, United States, 5 Department of Neurology, University of Minnesota, Minneapolis, MN, United States, 6 AP-HP, Hpital de la Salptrire, CENIR, Paris, France

Imaging of the hippocampus subparts with high resolution requires long acquisition time which can generate movement artifacts inside the images. This problem can be solved using multi-slab acquisitions which reduce acquisition time but require an accurate registration method to overcome inter-slab movement. We propose an efficient registration procedure for interleaved slab acquisitions. It consists in registering the slabs containing gaps to a reference image with SPM8 and homogenizing the intensities using synthetic phantoms. This registration method was tested and validated on two datasets acquired for hippocampus subparts imaging in two different centers for a total of 34 subjects. It proved robust for both multi-slab protocols.

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