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Abstract #4874

Perfluorocarbon Lung Clearance Evaluated with Dual-Nuclei 19 F and 1 H MRI in the Context of Total Liquid Ventilation

Ludovic de Rochefort 1 , Mourad Chenoune 2 , Anis Ben Yahmed 1 , Charlotte Alibert 1 , Jrmy Ppin 1 , Fanny Lidouren 2 , Lys Darbera 2 , Alain Berdeaux 2 , Matthias Korn 1 , Rose-Marie Dubuisson 1 , Luc Darrasse 1 , Daniel Isabey 3 , and Renaud Tissier 2

1 IR4M, Univ. Paris-Sud, CNRS, UMR 8081, Orsay, France, 2 Inserm UMR 955-3, Univ Paris Est, Ecole Nationale Vtrinaire de Maisons-Alfort, Maisons-Alfort, France, 3 Inserm UMR 955-13, Univ Paris Est, Crteil, France

Fast hypothermia induced by Total Liquid Ventilation (TLV) with Perfluorocarbons (PFC) has been shown to be cardioprotective. TLV procedure includes a lung filling phase, the ventilation, and a final clearance during which PFCs are eliminated from the lungs. For the potential clinical transfer, it is important to select PFCs that are better tolerated, as the clearance phase may vary with the PFC physical properties. Here, we present the evaluation of the clearance from pig lungs for three different liquid PFCs with a quantitative dual-nuclei (1H, 19F) MRI protocol at 1.5 T providing insights for selecting PFCs for human use

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