Abstract #4789
Altered sensorimotor network of resting state fMRI in Leukoaraiosis
Youzhi Lai 1 , Xia Wu 1,2 , and Li Yao 1,2
1
School of Information Science and
Technology, Beijing Normal University, Beijing, Beijing,
China,
2
State
Key Laboratory of Cognitive Neuroscience and Learning,
Beijing Normal University, Beijing, China
In this study, the sensorimotor network in resting state
fMRI was investigated by group ICA and correlation
analysis, for patients with leukoaraiosis (LA) and
healthy controls. The results showed significant
increased functional connectivity in medial volumes of
dorsal posterior precuneus (DP-PCC), left lingual and
supplementary motor area (SMA). Furthermore, the results
also revealed a strong correlation between the
visuospatial ability score of Montreal Cognitive
Assessment (MoCA) and the number of positive z-scores in
the DP-PCC. It was suggested that the motor dysfunction
in patient with LA maybe associated with the impairment
in visuospatial function.
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