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Abstract #4779

Evaluation of a multiparametric qBOLD (mqBOLD) and cerebrovascular reserve in patients with severe intracranial arterial stenosis : a comparison study

Julien Bouvier 1,2 , Olivier Detante 1,3 , Florence Tahon 4 , Arnaud Attye 4 , Thomas Perret 1 , David Chechin 2 , Irene Tropres 1,5 , Sylvie Grand 4,6 , Emmanuel L Barbier 1,6 , and Alexandre Krainik 1,4

1 U836, INSERM, Grenoble, France, France, 2 Philips Healthcare, Suresnes, France, France, 3 Department of neurology, Joseph Fourier University, France, France, 4 Department of neuroradiology and MRI, CHU de Grenoble, France, France, 5 IRMaGe facility, Joseph Fourier University, France, France, 6 Grenoble Institute of Neurosciences, Joseph Fourier University, France, France

To identify hemodynamic alteration related to steno-occlusive disease, functional MRI of cerebrovascular reserve (CVR fMRI) to hypercapnia has been proposed. A decreased vascular reserve downstream a severe intracranial arterial stenosis (SIAS) was associated with increased apparent diffusion coefficient, suggesting a chronic low-grade ischemia. However, relationships between hemodynamic disorder and metabolism has not been shown using MRI, yet. In such patients, these abnormalities may further motivate endovascular stenting. The aim of this study was to determine the relationships between tissular oxygen metabolism assessed with a multiparametric qBOLD (mqBOLD) approach with basal and functional changes of perfusion in patients with SIAS.

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