Meeting Banner
Abstract #4760

Isotropic and Anisotropic Measures of Anomalous Diffusion in Chronic Stroke Subjects

Carson Ingo 1 , Yu Fen Chen 2 , and Todd B. Parrish 2

1 C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2 Department of Radiology, Northwestern University, Chicago, IL, United States

In this study, we make use of anomalous diffusion measures in chronic stroke patients to better characterize tissue complexity in the left hemisphere, local to the necrotic regions, which often results in language deficits. To our knowledge, this is the first report to demonstrate application of the Continuous Time Random Walk (CTRW) theory and Entropy to model in vivo anomalous diffusion measurements in neurodegenerative subjects. In this study, FA(D) indicates the longitudinal fasciculus remains connected, however the complementary anisotropic information provided by α and H suggest the tissue microstructure is severely compromised, perhaps due to neurodegenerative processes or cell death.

This abstract and the presentation materials are available to members only; a login is required.

Join Here