Abstract #4760
Isotropic and Anisotropic Measures of Anomalous Diffusion in Chronic Stroke Subjects
Carson Ingo 1 , Yu Fen Chen 2 , and Todd B. Parrish 2
1
C. J. Gorter Center for High Field MRI,
Department of Radiology, Leiden University Medical
Center, Leiden, Netherlands,
2
Department
of Radiology, Northwestern University, Chicago, IL,
United States
In this study, we make use of anomalous diffusion
measures in chronic stroke patients to better
characterize tissue complexity in the left hemisphere,
local to the necrotic regions, which often results in
language deficits. To our knowledge, this is the first
report to demonstrate application of the Continuous Time
Random Walk (CTRW) theory and Entropy to model in vivo
anomalous diffusion measurements in neurodegenerative
subjects. In this study, FA(D) indicates the
longitudinal fasciculus remains connected, however the
complementary anisotropic information provided by α and
H suggest the tissue microstructure is severely
compromised, perhaps due to neurodegenerative processes
or cell death.
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