Abstract #4752
Cerebral Vascular Reactivity Impairment Contributes to Functional Connectivity Loss in the Transient MCAO Rat Brain
Xiao Wang 1 , Xiao-Hong Zhu 1 , Afshin A Divani 2 , and Wei Chen 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota Medical
School, Minneapolis, Minnesota, United States,
2
Neurology,
University of Minnesota, Minnesota, United States
Resting-state fMRI (rs-fMRI) provides a noninvasive and
unique way to study brain function organization and
connectivity in both healthy subjects and diseased
conditions. It is generally accepted that the
spontaneous hemodynamic signal fluctuations mainly
originate from the underlying neural activity, however,
the loss of spontaneous BOLD coherence at the resting
state may not exclusively result from the neuron origin
due to the complicated nature of the BOLD signal. The
effect of impaired cerebral vascular reactivity (CVR) on
rs-fMRI BOLD coherence was investigated by performing
CBF, CVR and rs-fMRI imaging on day 1 and day 7 post
1-hour occlusion in MCAO rat brain. It reveals that the
BOLD time courses for those lesion regions with
compromised CVR show flattened noise-like patterns with
much weak synchronization strength, while the coherence
partially resumes as the CVR recovers on day 7 after the
occlusion. The overall results demonstrate that the
hemodynamic response condition is important for the
study of the brain function connectivity while baseline
CBF might not be a good indicator of the state of
cerebral vascular reactivity.
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