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Abstract #4752

Cerebral Vascular Reactivity Impairment Contributes to Functional Connectivity Loss in the Transient MCAO Rat Brain

Xiao Wang 1 , Xiao-Hong Zhu 1 , Afshin A Divani 2 , and Wei Chen 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States, 2 Neurology, University of Minnesota, Minnesota, United States

Resting-state fMRI (rs-fMRI) provides a noninvasive and unique way to study brain function organization and connectivity in both healthy subjects and diseased conditions. It is generally accepted that the spontaneous hemodynamic signal fluctuations mainly originate from the underlying neural activity, however, the loss of spontaneous BOLD coherence at the resting state may not exclusively result from the neuron origin due to the complicated nature of the BOLD signal. The effect of impaired cerebral vascular reactivity (CVR) on rs-fMRI BOLD coherence was investigated by performing CBF, CVR and rs-fMRI imaging on day 1 and day 7 post 1-hour occlusion in MCAO rat brain. It reveals that the BOLD time courses for those lesion regions with compromised CVR show flattened noise-like patterns with much weak synchronization strength, while the coherence partially resumes as the CVR recovers on day 7 after the occlusion. The overall results demonstrate that the hemodynamic response condition is important for the study of the brain function connectivity while baseline CBF might not be a good indicator of the state of cerebral vascular reactivity.

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