Abstract #4746
Exploring amyloid-associated cerebral vasculopathy in an aged nonhuman primate model by multiparametric MRI
Silun Wang 1 , Jeromy Dooyema 2 , Xiaodong Zhang 1 , Lary C. Walker 2,3 , and Eric Heuer 2,4
1
Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA,
United States,
2
Yerkes
National Primate Research Center, Emory University, GA,
United States,
3
Department
of Neurology, Emory University, GA, United States,
4
University
of Hawaii at Hilo, HI, United States
We analyzed the histopathologic correlates of
age-associated vasculopathy in a unique nonhuman primate
model of cerebral β-amyloid angiopathy using
multiparametric MRI. Regions indicative of possible past
microbleeds were detected as hypointense regions via SWI,
and low ADC values were confirmed histologically to
contain abundant hemosiderin, β-amyloid deposition,
microgliosis and astrogliosis, but no demyelination. Our
results support the use of SWI and DTI as potential
imaging modalities to characterize cerebral vasculopathy
and associated degenerative changes in the senescent
brain.
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