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Abstract #4741

Regional White Matter disruption within the Corpus Callosum in patients with Mild Cognitive Impairment Single and Multiple domain

Elena Makovac 1 , Barbara Span 1 , Laura Serra 1 , Giovanni Giulietti 1 , Mario Torso 1 , Mara Cercignani 1,2 , Carlo Caltagirone 3,4 , and Marco Bozzali 1

1 Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy, 2 Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, United Kingdom, 3 Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy, 4 Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy

Two main clinical subtypes of amnestic MCI has been described, single-domain and multiple-domain aMCI In the present study we examined the Corpus Callosum (CC) by applying DTI-based tractography in SDamci and MDamci. Using a vixel-based approach, we were able to delineate a precise direction of WM damage inside the CC, starting from the Splenium in SDamci and proceeding toward the Genu in the MDamci, and eventually declining in a general CC WM damage in the final AD stage. These findings clarify some relevant aspects of AD pathophysiology and provide information of potential prognostic value for disease monitoring.

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