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Abstract #4736

Regional brain volume changes correlate with functional differences between APOE-e4+ and APOE-e4-

Nicholas G Dowell 1 , Simon L Evans 2 , Paul S Tofts 1 , Sarah L King 2 , Naji Tabet 3 , and Jennifer M Rusted 2

1 Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Falmer, Brighton and Hove, United Kingdom, 2 Psychology, University of Sussex, Falmer, Brighton and Hove, United Kingdom, 3 Postgraduate Medicine, Brighton and Sussex Medical School, Falmer, Brighton and Hove, United Kingdom

The presence of the APOE-e4 gene represents a significantly higher risk factor for developing Alzheimer's Disease. We scanned 80 healthy volunteers across two age-groups(young group: 20 with the e4 gene and 21 without, mid age group 17 with APOE-e4, 22 without). Our study identified local regional volume change in brain areas that positively correlated with fMRI activation between our two genetic groups. Brains areas identified were parahippocampus, cuneus, occipital and inferior parietal.

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