Abstract #4731
Degeneration of Functional and Structural Connection between the Two Hemispheres in AD and MCI
Jianli Wang 1 , Zhiqun Wang 2 , Han Zhang 3 , Robert Mchugh 1 , Xiaoyu Sun 1 , Kuncheng Li 2 , and Qing X. Yang 1,4
1
Radiology, Penn State College of Medicine,
Hershey, PA, United States,
2
Radiology,
Xuanwu Hospital of Capital Medical University, Beijing,
China,
3
Center for Cognition and Brain
Disorders, Hangzhou Normal University, Hangzhou,
Zhejiang, China,
4
Neurosurgery,
Penn State College of Medicine, Hershey, PA, United
States
Alzheimer's disease (AD) patients perform poorly on
tasks that require interhemispheric communication, which
suggests a deficit in the interhemispheric integration
of information. To investigate the relationship between
the interhemisphere functional deficits and degeneration
of the white matter connections in the AD, we
quantitatively measured interhemispheric functional
connectivity using resting-state fMRI and voxel-mirrored
homotopic connectivity method, together with the brain
diffusion parameters with diffusion tensor imaging in
the AD and mild cognitive impairment patients and
compared with those in the cognitive normal healthy
controls.
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