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Abstract #4731

Degeneration of Functional and Structural Connection between the Two Hemispheres in AD and MCI

Jianli Wang 1 , Zhiqun Wang 2 , Han Zhang 3 , Robert Mchugh 1 , Xiaoyu Sun 1 , Kuncheng Li 2 , and Qing X. Yang 1,4

1 Radiology, Penn State College of Medicine, Hershey, PA, United States, 2 Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China, 3 Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, Zhejiang, China, 4 Neurosurgery, Penn State College of Medicine, Hershey, PA, United States

Alzheimer's disease (AD) patients perform poorly on tasks that require interhemispheric communication, which suggests a deficit in the interhemispheric integration of information. To investigate the relationship between the interhemisphere functional deficits and degeneration of the white matter connections in the AD, we quantitatively measured interhemispheric functional connectivity using resting-state fMRI and voxel-mirrored homotopic connectivity method, together with the brain diffusion parameters with diffusion tensor imaging in the AD and mild cognitive impairment patients and compared with those in the cognitive normal healthy controls.

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