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Abstract #4721

Verification of impaired vasoreactivity in subjects with Cerebral Amyloid Angiopathy: A post-hoc analysis of visual-stimulus fMRI

James A Goodman 1 , Mark R Austin 2 , Andrea S Les 2 , Zhiyong Xie 1 , Yao Zhang 3 , and Claire Leurent 4

1 Precision Medicine - Clinical and Translational Imaging, Pfizer Inc, Groton, CT, United States, 2 IXICO plc, London, United Kingdom, 3 PharmaTherapeutic Statistics, Pfizer Inc, Cambridge, MA, United States, 4 Neuroscience Research Unit, Pfizer Inc, Cambridge, MA, United States

Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid deposition and has been shown to be associated with reduced cerbrovascular reactivity in transgenic animal models and in a cohort of human subjects. In this work we attempt to replicate previously-published findings in an independent cohort of CAA subjects and age-matched controls by performing a retrospective analysis of the ascending slope of the hemodynamic response to visual stimulus fMRI. Despite differing field strengths, acquisition protocols and analysis pipelines, a similar observation of significantly reduced cerebrovascular reactivity was observed, demonstrating the robust nature of this characteristic of CAA.

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