Abstract #4717
Spatiotemporal Characterization of Neurodegeneration in the Visual System upon Acute and Chronic Optic Neuropathies using Diffusion Tensor MRI
Leon C. Ho 1,2 , Ian P. Conner 3 , Seong-Gi Kim 1,4 , Ed X. Wu 2 , Gadi Wollstein 3 , Joel S. Schuman 3 , and Kevin C. Chan 1,3
1
Neuroimaging Laboratory, Department of
Radiology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Department
of Ophthalmology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
4
Center
for Neuroscience Imaging Research, Institute for Basic
Science (IBS), Dept. of Biological Sci, SKKU, Suwon,
Korea
This study determined spatiotemporally the progression
of microstructural disorganization in acute and chronic
optic neuropathies of different severity using diffusion
tensor MRI so as to better understand the mechanisms of
pathological processes such as glutamate excitotoxicity,
and in neurodegenerative diseases such as ocular
hypertension and glaucoma. Our data suggested
anterograde degeneration along the visual pathway upon
acute glutamate excitotoxic retinal injury with varying
rates of λ// and λ┴ changes along time. In addition,
mild, early distal axonopathy might be detected in vivo
along the visual pathway upon chronic ocular
hypertension.
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