Abstract #4700
Quantitative assessment of the substantia nigra, red and subthalamic nuclei in Parkinsons disease using susceptibility weighted imaging
Jason Langley 1 , Jan Sedlacik 2 , Xiaoping Hu 1 , Jens Fiehler 2 , and Kai Boelmans 3
1
Wallace H. Coulter Department of Biomedical
Engineering, Georgia Institute of Technology and Emory
University, Atlanta, GA, United States,
2
Department
of Neuroradiology, University Medical Center Hamburg-Eppendorf
(UKE), Hamburg, Germany,
3
Department
of Psychiatry, University Medical Center Hamburg-Eppendorf
(UKE), Hamburg, Germany
The substantia nigra, subthalamic nucleus, and red
nucleus are important structures in the study of
Parkinsons disease and all three structures contain
high concentrations of iron. A hallmark of Parkinsons
disease is the increased deposition of iron in the
substantia nigra and red nucleus as well as the loss of
dopaminergic neurons in the substantia nigra. This study
compares volumetric estimates of the substantia nigra,
subthalamic nucleus, and red nucleus. Statistically
significant volumetric difference between parkinsons
disease and control groups in the red nucleus and the
phase difference between the two groups in the
substantia nigra are reported.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
