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Abstract #4698

Age-related increased R2 and R2* in the C57BL/6J mouse Basal Ganglia correlated with elevated iron levels measured by synchrotron-radiation X-ray fluorescence

Thomas Walker 1 , Christos Michaelides 1 , Harry Parkes 2 , William Crum 1 , Amy Herlihy 3 , and Po-Wah So 1

1 Department of Neuroimaging, Institute of Psychiatry, King's College London, London, United Kingdom, 2 CR-UK Clinical MR Research Group, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3 Agilent technologies, Yarnton, Oxfordshire, United Kingdom

Brain iron accumulation with ageing may play a role in senescent processes, with age-related increases in basal ganglia R2 and R2* observed in man and associated with increased iron. Here, we show similar increases in R2 and R2* values of the basal ganglia in aged C57BL/6J mice compared to young. Subsequent direct measurement of iron by synchrotron radiation X-ray fluorescence elemental iron mapping suggests the increased R2 and R2* values here may indeed arise from higher iron concentrations in this region. Thus, iron dyshomeostasis may play a role in ageing and MR relaxometry may be used to monitor ageing processes.

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