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Abstract #4696

A selective ageing effect on the frontal lobe connections

Michel Thiebaut de Schotten 1,2 , Katrine Rojkova 1 , Marika Urbanski 1 , Frederic Humbert 1 , Flavio Dell'Acqua 2 , and Emmanuelle Volle 1

1 Brain and Spine Institute, Paris, France, 2 Natbrainlab - Institute of Psychiatry, London, United Kingdom

Cognitive decline affects predominantly executive functions, and brain changes seem to distribute unevenly, concerning predominantly the frontal region. Hence, the study of the frontal connections is of particular interest for the neurosciences of ageing. Here our results suggest for the first time that aging alters significantly specific long and short tracts in the frontal lobes which brings up interesting hypotheses on a pathophysiological explanation for aging decline in visuospatial and verbal working memory, memory encoding and retrieval, reward-based associative learning that can be tested in the elderly.

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