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Abstract #4694

Investigation of Age-related Changes in Blood Oxygenation Level Dependency Signals during the visuospatial N-back using Functional MRI

Mitsunobu Kunimi 1 , Sachiko Kiyama 1 , and Toshiharu Nakai 1

1 National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

We compared the association between task difficulty and cerebral activity during visual N-back task between the young and elderly groups using blood oxygenation level dependency fMRI. The change of percent signal change depending on task difficulty shows reduction in the up-regulation of the regions responsible for visuospatial working memory in response to increasing task demands in the elderly. It was suggested that the regulation ability of load of visuospatial working memory was decline depending on age. It might cause that elderly cannot utilize visuospatial working memory efficiently.

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