Abstract #4684
Diffusional Kurtosis Imaging of White Matter in the Aging Brain
Andreana Benitez 1 , Clifford Chan 1 , Ali Tabesh 1 , Jensen H. Jensen 1 , and Joseph A. Helpern 1
1
Center for Biomedical Imaging, Department of
Radiology and Radiological Science, Medical University
of South Carolina, Charleston, SC, United States
Using Diffusional Kurtosis Imaging (DKI), we found
significant decline in mean, axial, and radial kurtoses
in white matter (WM) in the aging brain (N=27, ages
55-83). We also found that these metrics were correlated
with executive functions (i.e. Trailmaking Test-Part B),
primarily in fronto-parietal regions, over and above the
effect of age. Consistent with and in extension of prior
literature, our results highlight the pervasiveness of
WM degeneration in the aging brain and its association
with executive functions, using a clinically viable
innovation in diffusion MRI.
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