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Abstract #4679

Dyslipidemia and hypertension as cerebral blood flow predictors in the CRESCENDO cohort of elderly subjects.

Jeremy Deverdun 1,2 , Tasnime Akbaraly 3 , Frederic Ben Naim 4 , Alain Bonafe 5 , Adam Brickman 6 , Celine Charroud 3 , Stephane Chemouny 1 , Jeannette Fareh 7 , Nicolas Menjot de Champfleur 5 , Franois Molino 8 , Olivier Soulier 4 , Jason Steffener 6 , Florence Portet 3 , Yaakov Stern 6 , Karen Ritchie 3 , and Emmanuelle Le Bars 5

1 Intrasense, Montpellier, Herault, France, 2 Theoretical Physics, Universite Montpellier 2, Montpellier, Herault, France, 3 Unit 1061 : Neuropsychiatry: Epidemiological and clinical research, Inserm, Herault, France, 4 Intrasense, Herault, France, 5 Service de neuroradiologie, CHU Gui de Chauliac, Montpellier, Herault, France, 6 The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, United States, 7 SysDiag UMR3145, CNRS, Herault, France, 8 Theoritical Physics, Universite Montpellier 2, Montpellier, Herault, France

Cerebral blood flow (CBF) is an important factor in brain function. We to assess the link between quantified gray matter CBF and epidemiological factors obtained 12 years before, on a large cohort of elderly subjects. Mean and regional CBF were obtained from Pulsed Arterial Spin Labeling sequence after correction for white matter lesion and partial volume effect. Results exhibit significant decrease in CBF in dyslipidemia and an increase in hypertension. The regional analysis highlights localization of these modifications in posterior circulation territories (hypertension), and regions of the anterior circulation (dyslipidemia). Those two factors seems able to predict CBF variations.

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