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Abstract #4676

Measuring the effects of aging and gender on regional brain shear stiffness in healthy volunteers with MR Elastography

John Huston 1 , Arvin Arani 1 , Matthew C Murphy 1 , Kevin J Glaser 1 , Armando Manduca 2 , David S Lake 2 , Scott Kruse 1 , Clifford R Jack 1 , and Richard Ehman 1

1 Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2 Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States

Objective: To evaluate global and regional brain stiffness as a function of age and gender using an improved magnetic resonance elastography (MRE) approach. Methods: Full volume 3-dimensional brain stiffness measurements were acquired in a total of 45 healthy amyloid-negative, cognitively normal subjects in the age range of 56-89 years. Results: Significant negative correlations between age and brain stiffness were observed in the cerebrum and the frontal, parietal, occipital, and temporal lobes. A significant gender bias was also observed in the occipital and temporal lobes. Conclusions: These results suggest both age and gender impact stiffness in certain regions of the brain.

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