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Abstract #4666

Reproducibility of BOLD and CBF responses to fixed step changes in inspired O 2 /CO 2 using dual-echo pCASL

Felipe B Tancredi 1 , Isabelle Lajoie 1 , Danny J Wang 2 , and Richard D Hoge 1

1 Centre de recherche de l'IUGM, Montreal, QC, Canada, 2 Neurology, University of California, Los Angeles, CA, United States

Functional MRI of BOLD and CBF responses to blood gas manipulations have been used to characterize cerebral vascular reactivity and calibrate physiological models allowing estimation of CMRO 2 . Characterizing the test-retest reliability of such measures will aid in power calculations required for future research and clinical applications. We have determined the coefficient of variation for BOLD and CBF responses to hypercapnia/hyperoxia using step changes in inspired CO 2 /O 2 to manipulate these blood gases, and a dual-echo pCASL sequence to simultaneously image blood flow and oxygenation. We have found that pCASL measures of BOLD and CBF in grey-matter were robust and consistent.

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