Abstract #4666
Reproducibility of BOLD and CBF responses to fixed step changes in inspired O 2 /CO 2 using dual-echo pCASL
Felipe B Tancredi 1 , Isabelle Lajoie 1 , Danny J Wang 2 , and Richard D Hoge 1
1
Centre de recherche de l'IUGM, Montreal, QC,
Canada,
2
Neurology,
University of California, Los Angeles, CA, United States
Functional MRI of BOLD and CBF responses to blood gas
manipulations have been used to characterize cerebral
vascular reactivity and calibrate physiological models
allowing estimation of CMRO
2
. Characterizing
the test-retest reliability of such measures will aid in
power calculations required for future research and
clinical applications. We have determined the
coefficient of variation for BOLD and CBF responses to
hypercapnia/hyperoxia using step changes in inspired CO
2
/O
2
to
manipulate these blood gases, and a dual-echo pCASL
sequence to simultaneously image blood flow and
oxygenation. We have found that pCASL measures of BOLD
and CBF in grey-matter were robust and consistent.
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