Abstract #4663
Changes in Functional Connectivity during Propofol Anesthesia as Evaluated with Intrinsic Connectivity Distribution
Maolin Qiu 1 , Ramachandran Ramani 2 , Dustin Scheinost 1 , and Robert Todd Constable 1,3
1
Diagnostic Radiology, Yale School of
Medicine, New Haven, Connecticut, United States,
2
Anesthesiology,
Yale School of Medicine, New Haven, Connecticut, United
States,
3
Biomedical
Engineering, and Neurosurgery, Yale School of Medicine,
New Haven, Connecticut, United States
Intrinsic functional connectivity contrast (ICC) has
been used to examine the effects of anesthetics on the
human brain, but several issues have been problematic,
one of which is that a correlation threshold has to be
arbitrarily chosen and different thresholds may yield
different results. A new approach based on the intrinsic
connectivity distribution (ICD) was proposed to
eliminate the need to choose a threshold. In this work
we report the anesthetic effects of propofol on
functional connectivity based on the ICD method and the
results are compared with those obtained using ICC.
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