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Abstract #4659

Metabolic aberrations underlying impaired abstract reasoning abilities in chronic alcoholism: A proton magnetic resonance spectroscopy imaging study

Deepika Bagga 1 , Shilpi Modi 1 , Prabhjot Kaur 1 , Mohan lal Garg 2 , Debajyoti Bhattacharya 3 , Subash Khushu 1 , and Namita Singh 1

1 NMR Research centre, INMAS, Delhi, delhi, India, 2 Department of Biophysics, Panjab University, Chandigarh, Punjab, India, 3 Department of psychiatry, Base Hospital, Delhi, delhi, India

Proton in vivo Magnetic Resonance Spectroscopy (MRS) study on frontal and parietal brain regions was performed on alcohol dependents and healthy controls to look for the metabolic aberrations underlying the abstract reasoning deficits observed in alcohol dependents as shown by a recent fMRI study at our centre. This study suggested the probable role of fronto-parietal circuit for poorer abstract reasoning abilities. A significant reduction in NAA/Cr and Glx/Cr ratios and a significant increase in Cho/Cr and Ins/Cr ratios was observed which could possibly account for impaired abstract reasoning abilities in alcohol dependents.

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