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Abstract #4622

Alterations in Cardiac-Correlated Brain BOLD Signal in Children with Chronic Kidney Disease

Hua-Shan Liu 1 , Abbas F. Jawad 2 , Nina Laney 2 , Stephen Hooper 3 , Jerilynn Radcliffe 2 , Divya Moodalbail 2 , Christos Davatzikos 1 , Robert Schultz 2 , Susan Furth 2 , and John Detre 1

1 University of Pennsylvania, Philadelphia, PA, United States, 2 The Childrens Hospital of Philadelphia, Philadelphia, PA, United States, 3 University of North Carolina School of Medicine, Chapel Hill, NC, United States

We investigated the group difference of the cardiovascular fluctuation-induced modulation in BOLD fMRI signal between patients with chronic kidney disease (CKD) and control subjects. We found that CKD patients showed a significantly increased cardiac modulation in BOLD fMRI in the anterior cingulated cortex as compared with control subjects.

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