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Abstract #4620

Abnormal cortical and thalamic development in children with Borderline Intellectual Functioning

Niels Bergsland 1,2 , Francesca Baglio 1 , Gisella Baglio 1 , Raffaello Nemni 1,3 , Mario Clerici 1,3 , Michela Zanette 1 , and Valeria Blasi 1

1 Istituto IRCCS Santa Maria Nascente, Fondazione Don Gnocchi, Milan, Italy, 2 Dipartimento di Elettronica, Informatica e Bioingegneria, Politecnico di Milano, Milan, Italy, 3 Universit degli Studi di Milano, Milan, Italy

Borderline Intellectual Functioning (BIF) children present with cognitive, motor, social and adaptive limitations that result in learning disabilities and are more likely to develop psychiatric disorders later in life. It has become increasingly recognized that gray matter plays a significant role in this condition. The current study compared BIF and typically developing groups of children in measures of cortical thickness/area as well as subcortical structural volumes in BIF. It was shown that BIF children present with brain development delay in cortical areas and that thalamus which are associated with motor and cognitive abilities crucial for intellectual functioning.

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