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Abstract #4614

Regional Microstructure And Volume Abnormalities In The Corpus Callosum Of Neonates With Transposition Of The Great Artery Undergoing Cardiopulmonary By Pass Surgery.

Malek Makki 1 , Jitka Majerova 2 , Walter Knirsch 3 , Beatrice Latal 4 , and Cornelia Hagmann 2

1 MRI Research, Univesity Children Hospital of Zurich, Zurich, Switzerland, 2 Neonatalogy, University Hospital of Zurich, Switzerland, 3 Cardiology, University Children Hospital of Zurich, Switzerland, 4 Child Development Center, University Children Hospital of Zurich, Switzerland

DTI and 3D volumetric acquisitions were preformed on 15 neonates with transposition of the great artery before and after surgery and compared to 20 age matched healthy controls. We subdivided the corpus callosum into 5 parts: genu, rostrum, body, isthmus, and splenium and compared their volume and their DTI indices. Pre and post surgical patients had significantly lower sub-structural volumes compare to healthy controls but no correlation with DTI indices. Altered DTI indices were observed in all sub-structures in the post surgical group while pre-surgical patients showed altered DTI indices in the splenium and rostrum.

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