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Abstract #4610

Longitudinal TBSS study of preterm and at term newborns

Paola Scifo 1 , Elisa Marchetta 2,3 , Silvia Pontesilli 2 , Elisa Scola 2 , Antonella Poloniato 4 , Graziano Barbera 4 , Antonella Iadanza 2 , Andrea Falini 2,5 , and Cristina Baldoli 2

1 Nuclear Medicine, Ospedale San Raffaele, Milan, -, Italy, 2 Neuroradiology, Ospedale San Raffaele, Milan, -, Italy, 3 Univerist degli Studi di Milano Bicocca, Milano, -, Italy, 4 Pediatric Department, Ospedale San Raffaele, Milan, -, Italy, 5 Universit Vita-Salute San Raffaele, Milan, -, Italy

Brain maturation in the early ages of life is characterized by crucial microstructural changes. This work aims to study the different development of White Matter in pre-term newborns with respect to those born at term, by using TBSS for the statistical comparison of DTI FA and MD maps acquired on a 3T scanner. The results show an advanced brain maturation in term vs preterm infants at 40 weeks PMA and a progressive maturation of preterm brains in the three ages of acquisition, demonstrating the feasibility of TBSS analysis on DTI data for the evaluation of myelination process.

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