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Abstract #4582

Dynamic Contrast Enhanced (DCE)-MRI and Circulating Angiogenic Factors for Monitoring of Antiangiogenic Effect of Bevacizumab in Colorectal Cancer Liver Metastasis

Bio Joo 1 , Mi-Suk Park 1 , Yeo-Eun Kim 1 , and Sang-Joon Shin 2

1 Department of Radiology and Research Institute of Radiological Science, Yonsei University College of, Seoul, Korea, 2 Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea

We assessed the clinical outcomes of colorectal cancer liver metastasis (CRCLM) patients treated with Bevacizumab plus FOLFOX by Dynamic Contrast Enhanced (DCE)-MR imaging and plasma cytokines and angiogenic factors (CAFs). Significant changes in DCE-MRI and CAFs on 3 day after bevacizumab monotherapy proved anti-angiogenic effect of bevacizumab monotherapy. Higher baseline iAUC60 and early reduction of Ktrans could predict longer PFS in the patients with CRCLM.

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