Meeting Banner
Abstract #4577

Comparison of CBF Augmentation with Diamox Challenge Using Arterial Spin Labeling and Xenon CT in Moyamoya Disease

Zungho Zun 1 , R. Marc Lebel 2 , Deqiang Qiu 3 , Ajit Shankaranarayanan 4 , and Greg Zaharchuk 1

1 Stanford University, Stanford, CA, United States, 2 GE Healthcare, Calgary, AB, Canada, 3 Emory University, Atlanta, GA, United States, 4 GE Healthcare, Menlo Park, CA, United States

Cerebral blood flow (CBF) reactivity to vasodilation provides better prognosis for vascular disease, and arterial spin labeling (ASL) may be ideal for this because of no burden of ionizing radiation or contrast agents. In this study, four different ASL methods were performed in subsets of sixteen moyamoya disease patients before and after acetazolamide (ACZ) injection and were compared to the reference standard xenon CT CBF with ACZ. Multi-delay PCASL showed the highest correlation with xenon CT in measuring CBF. For measuring CBF augmentation, however, all three PCASL methods showed similar correlation and VS-ASL showed lower correlation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here