Abstract #4577
Comparison of CBF Augmentation with Diamox Challenge Using Arterial Spin Labeling and Xenon CT in Moyamoya Disease
Zungho Zun 1 , R. Marc Lebel 2 , Deqiang Qiu 3 , Ajit Shankaranarayanan 4 , and Greg Zaharchuk 1
1
Stanford University, Stanford, CA, United
States,
2
GE
Healthcare, Calgary, AB, Canada,
3
Emory
University, Atlanta, GA, United States,
4
GE
Healthcare, Menlo Park, CA, United States
Cerebral blood flow (CBF) reactivity to vasodilation
provides better prognosis for vascular disease, and
arterial spin labeling (ASL) may be ideal for this
because of no burden of ionizing radiation or contrast
agents. In this study, four different ASL methods were
performed in subsets of sixteen moyamoya disease
patients before and after acetazolamide (ACZ) injection
and were compared to the reference standard xenon CT CBF
with ACZ. Multi-delay PCASL showed the highest
correlation with xenon CT in measuring CBF. For
measuring CBF augmentation, however, all three PCASL
methods showed similar correlation and VS-ASL showed
lower correlation.
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