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Abstract #4573

Decrease in intracranial vascular compliance is associated with cerebral hypoperfusion

Lirong Yan 1 , Collin Liu 2 , Robert Smith 1 , John Ringman 1 , and Danny JJ Wang 1

1 University of California Los Angeles, Los Angeles, CA, United States, 2 University of Southern California, CA, United States

Both arterial stiffening (or reduced vascular compliance) and cerebral hypoperfusion have been found to be associated with aging and dementia. The purpose of this study is to investigate the relationship between intracranial vascular compliance and perfusion measured using a novel dynamic arterial-spin labeling (ASL) technique and pseudo-continuous ASL 3D GRASE MRI respectively. The results show that vascular compliance and perfusion are correlated with each other and both decrease with aging and vascular risks. This study supports arterial stiffening and cerebral hypoperfusion as markers of vascular risks and dementia.

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