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Abstract #4564

Low Power Adiabatic Inversion for Arterial Spin Labeling

Ovidiu Cristian Andronesi 1 , Uvo C. Hoelscher 2 , Himanshu Bhat 3 , Keith Heberlein 3 , and Bruce R. Rosen 1

1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2 Siemens Healthcare, AG, Erlangen, Bayern, Germany, 3 Siemens Healthcare USA, Boston, MA, United States

Improving SNR is critical for the ASL methods. Inversion of magnetization of the blood spins is a main factor responsible for the SNR in ASL. With the ongoing trend in the development of MR hardware towards large-bore scanners and the active control of the RFPA duty cycle there is an increased need for efficient and low-power adiabatic inversion. Here we present the use of Gradient Offset Independent Adiabaticity GOIA-W(16,4) pulses for low power adiabatic tagging of blood in ASL sequences. GOIA pulses require only half of the B1max of the FOCI pulses that are typically used in ASL. Hence, the B1max of GOIA pulses is not clipped and can be increased above the adiabatic threshold allowing to compensate for B1 inhomogeneity. Perfusion maps obtained in human brain show that SNR is improved overall with GOIA pulses. Largest SNR gain (50%) is noticed especially in the middle of the brain as expected from simulations.

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