Abstract #4555
Neurotoxic aspects of tungusten Alloy Based Heavy Metals in Rat Brain: A DTI study
Ritu Tyagi 1 , Poonam Rana 1 , Richa Trivedi 1 , B.S. Hemanth Kumar 1 , Deepak Bhatnagar 2 , and Subash Khushu 1
1
NMR Research centre, Institute of Nuclear
Medicine and Allied Sciences (INMAS), DELHI, DELHI,
India,
2
School
of Biochemistry, Devi Ahilya Vishwavidayalaya, Indore,
M.P., India
HMTAs are composed of a mixture of tungsten (9193%),
nickel (35%) and either cobalt (24%) or iron (24%)
particles which are increasingly adopted as the raw
material to make parts of military products. Diffusion
tensor imaging (DTI) study was performed at day 1, day
3, and day 5 in controls and animals treated metals used
in HMTAs and their mixture. An increase in MD values
were observed in cerebral pedeuncle with cobalt and
tungsten, whereas all the three metal salts and their
mixture showed pronounced effect on the thalamic region
of the brain compared to controls.
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