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Abstract #4555

Neurotoxic aspects of tungusten Alloy Based Heavy Metals in Rat Brain: A DTI study

Ritu Tyagi 1 , Poonam Rana 1 , Richa Trivedi 1 , B.S. Hemanth Kumar 1 , Deepak Bhatnagar 2 , and Subash Khushu 1

1 NMR Research centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DELHI, DELHI, India, 2 School of Biochemistry, Devi Ahilya Vishwavidayalaya, Indore, M.P., India

HMTAs are composed of a mixture of tungsten (9193%), nickel (35%) and either cobalt (24%) or iron (24%) particles which are increasingly adopted as the raw material to make parts of military products. Diffusion tensor imaging (DTI) study was performed at day 1, day 3, and day 5 in controls and animals treated metals used in HMTAs and their mixture. An increase in MD values were observed in cerebral pedeuncle with cobalt and tungsten, whereas all the three metal salts and their mixture showed pronounced effect on the thalamic region of the brain compared to controls.

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