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Abstract #4540

Assessment of aquaporins function in stages of liver fibrosis using multi-b diffusion weighted magnetic resonance imaging

LI Qiu-ju 1 , ZHANG Zi-heng 2 , LI Jia-hui 1 , YU Bing 1 , ZHANG Xin 1 , ZHAO Zhou-she 2 , SHI Yu 1 , XIN Jun 1 , and GUO Qi-yong 1

1 Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China, 2 General Electronic Company Healthcare (China), Beijing, China

A multi-b diffusion weighted MR imaging measurement was performed to examine the effects of AQP inhibition to normal and liver-fibrotic rats in vivo. At low-b values, the resulted ADCs reflected the hepatic blood perfusion information while the functional changes of the AQPs on cell membranes at high b values. The AQP1 expression in the liver endothelial cells increased with aggravation of liver fibrosis. An increase of perfusion was observes at S1, but a decrease occurred with the addition of inhibitor. At S2, perfusion decreased, and further decreased with inhibitor. The inhibition tests were all negative.

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