Abstract #4540
Assessment of aquaporins function in stages of liver fibrosis using multi-b diffusion weighted magnetic resonance imaging
LI Qiu-ju 1 , ZHANG Zi-heng 2 , LI Jia-hui 1 , YU Bing 1 , ZHANG Xin 1 , ZHAO Zhou-she 2 , SHI Yu 1 , XIN Jun 1 , and GUO Qi-yong 1
1
Radiology, Shengjing Hospital of China
Medical University, Shenyang, Liaoning, China,
2
General
Electronic Company Healthcare (China), Beijing, China
A multi-b diffusion weighted MR imaging measurement was
performed to examine the effects of AQP inhibition to
normal and liver-fibrotic rats in vivo. At low-b values,
the resulted ADCs reflected the hepatic blood perfusion
information while the functional changes of the AQPs on
cell membranes at high b values. The AQP1 expression in
the liver endothelial cells increased with aggravation
of liver fibrosis. An increase of perfusion was observes
at S1, but a decrease occurred with the addition of
inhibitor. At S2, perfusion decreased, and further
decreased with inhibitor. The inhibition tests were all
negative.
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