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Abstract #4533

Aging in White Matter Revealed by Diffusional Kurtosis Imaging

Nan-Jie Gong 1,2 , Chun-Sing Wong 1 , Chun-Chung Chan 3 , Lam-Ming Leung 4 , Yiu-Ching Chu 5 , and Queenie Chan 6

1 Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, 2 Radiology, Stanford University, Stanford, CA, United States, 3 Geriatrics & Medicine, United Christian Hospital, Hong Kong, China, 4 Psychiatry, United Christian Hospital, Hong Kong, China, 5 Radiology, Kwong Wah Hospital, Hong Kong, China, 6 Philips Healthcare, Hong Kong, China

We utilized DKI, and for the first time a white-matter-model that provided metrics of explicit neurobiological interpretations in cognitive aging adults. Whole brain TBSS and regional results suggested that age-related white matter degenerations were broadly driven by axonal loss across nearly all tracts. In the anterior brain which is mostly composed of the late-myelinated fibre tracts, demyelination was also a major mechanism contributing to disintegration. Such probable coexistence of both mechanisms was in line with the Wallerian degeneration theory and is more supportive of the anterior-posterior gradient degeneration than the retrogenesis theory.

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