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Abstract #4527

Evaluation of diffusion acquisition and tractography methods for neurosurgical planning systems

Jonathan Ashmore 1 , Flavio Dell'Acqua 2 , Ruth O'Gorman 3 , Gareth Barker 2 , and Jozef Jarosz 1

1 Neuroradiology, Kings College Hospital, London, United Kingdom, 2 Department of Neuroimaging, Kings College London, London, United Kingdom, 3 University Children's Hospital, Zurich, Switzerland

The purpose of this study was to investigate how diffusion acquisition parameters including the number of diffusion directions, the use of cardiac gating and the use of non-isotropic versus isotropic voxels impacts on tractography of the corticospinal tract for application to neurosurgical planning. We consider the tractography generated from a regulatory approved neurosurgical planning system to those produced from research software which incorporates constrained spherical deconvolution and probabilistic tractography. All tractography results are assessed against cyctoarchitectonic maps of the corticospinal tract which is used as a gold standard to asses the validity of the generated tracts.

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