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Abstract #4523

Analysis of the generalized fractional anisotropy in regions of fiber crossings: a simulation study

Jennifer Andreotti 1 , Alessandra Griffa 2 , Thomas Dierks 1 , Andrea Federspiel 1 , and Patric Hagmann 2,3

1 University Psychiatric Hospital, Bern, BE, Switzerland, 2 Swiss Federal Institute of Technology, Lausanne, VD, Switzerland, 3 CHUV, Lausanne, VD, Switzerland

Quantitative tractography methods require a detailed characterization of tissue properties specific to each white matter (WM) fiber tract. In our study Monte-Carlo simulations are used to understand how the generalized fractional anisotropy (GFA) is affected in the case of variable configurations of WM fiber tracts crossings. In particular, a linear sum of specific anisotropy measures for each of the tracts (linGFA) is compared to the usual GFA. The analysis shows that, compared to standard GFA, linGFA has a more linear relationship with the underlying characteristics of each of the fiber tracts and hence would be beneficial for quantitative tractography studies.

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