Estimation of brain perfusion using flow-compensated intravoxel incoherence motion MRI: a simulation study

Small blood volume of brain limits the application of IVIM-MRI. Hypoperfusion is an important index for diagnosis of some brain diseases. However, without sufficient signal-noise ratio, large estimation errors may be yielded in conditions of small cerebral blood volume (CBV) and cerebral blood flow (CBF). In this study, we proposed a method using conventional diffusion weighted imaging combined with flow-compensated pulses to estimate the CBF-related parameter. Computer simulation was performed to evaluate the accuracy and precision in heterogeneous brain tissues. The results showed that the proposed method can estimate extremely low CBF with better precision than the conventional fitting method.

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