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Abstract #4505

Temperature-controlled Isotropic Diffusion Phantom with Wide Range of Apparent Diffusion Coefficients for Multicenter Assessment of Scanner Repeatability and Reproducibility

Michael A. Boss 1 , Thomas L. Chenevert 2 , John C. Waterton 3,4 , David M. Morris 4 , Hossein Ragheb 4 , Alan Jackson 4 , Nandita deSouza 5 , David J. Collins 5 , Bernard E. van Beers 6 , Philippe Garteiser 6 , Sabrina Doblas 6 , Stephen E. Russek 1 , Kathryn E. Keenan 1 , Edward F. Jackson 7 , and Gudrun Zahlmann 8

1 National Institute of Standards and Technology, Boulder, CO, United States, 2 University of Michigan, Ann Arbor, MI, United States, 3 AstraZeneca, Macclesfield, United Kingdom, 4 University of Manchester, Manchester, United Kingdom, 5 The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 6 INSERM, France, 7 University of Wisconsin, Madison, WI, United States, 8 F. Hoffman-La Roche Ltd., Basel, Switzerland

We designed and built an ADC phantom to cover a wide range of physiologically relevant ADC values. The phantom used aqueous solutions of polyvinylpyrrolidone (PVP), and we maintained constant temperature by filling the phantom with ice water. The phantom was scanned at three sites (1.5 and 3.0 T) to assess variability of ADC measurement. We found excellent intrascanner repeatability and good reproducibility across systems and field strengths. There was non-negligible variability only for the highest concentrations of PVP, representing ADCs less than 0.3 x 10 -3 mm 2 /s. The ADC of water at 0 °C was in excellent agreement with literature values of 1.1 x 10 -3 mm 2 /s.

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