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Abstract #4497

Comparison of Fitting Methods and b value Sampling Strategies for Intravoxel Incoherent Motion (IVIM) in Breast Cancer

Gene Young Cho 1 , Jeff L Zhang 2 , Linda Moy 1,3 , Steven Baete 1 , Melanie Moccaldi 3 , Sungheon Kim 1 , Daniel K Sodickson 1 , and Eric E Sigmund 1

1 Radiology - Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, Select, United States, 2 Radiology, University of Utah, Salt Lake City, UT, United States, 3 Radiology, New York University Cancer Institute, New York, NY, United States

The selection of diffusion gradients for diffusion weighted imaging (DWI) is important for protocol optimization. It has been shown that different ranges of gradients sensitize the signal to different components of diffusion. Additionally, quantification of DWI data with the biexponential IVIM fitting model can be numerically nontrivial. In this study, we employ an optimized b value selection for biexponential IVIM analysis of breast lesions to increase measurement precision. Eventually, optimization may lead to increasing diagnostic differentiation between cancerous subtypes and potentially allow more careful monitoring of response to treatment.

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