Abstract #4495
Demonstration of fast diffusion kurtosis MRI for imaging acute ischemic stroke diffusion/kurtosis lesion mismatch
Phillip Zhe Sun 1 , Yu Wang 1,2 , Emiri Mandeville 3 , Eng H Lo 3 , and Xunming Ji 2
1
Radiology, Martinos Center for Biomedical
Imaging, Charlestown, MA, United States,
2
Cerebrovascular
Diseases Research Institute, Xuanwu Hospital of Capital
Medical University, Beijing, China,
3
Department
of Radiology and Neurology, Neuroprotection Research
Laboratory, MA, United States
Diffusion kurtosis MRI (DKI) is a complementary index to
stratify heterogeneous DWI deficit. However, DKI
acquisition time is relatively long. Here, we tested a
fast DKI approach, recently proposed by Hansen et al.,
using a rodent model of acute stroke. We found
significant correlation, per pixel, between the
diffusion and kurtosis coefficients measured using the
standard and fast DKI protocols. We further demonstrated
that diffusion and kurtosis lesion sizes defined using
the fast and conventional DKI methods were in good
agreement. Moreover, we showed that kurtosis lesion size
was significantly smaller than that of diffusion lesions
(7216%, P<0.01, Paired-t test).
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